Browns vs 49ers are 19-9 throughout history. That number is important, it shows how much the Brownies have dominated this NFC team all the way back to the days of Otto.
Next is the 49ers schedule this year. So far they've played the Buccaneers 2-3, Steelers 1-4 with a 2nd string QB and the Bengals who are 0-5. Not one of those teams is even comparable to the Browns.
Toss in Chubb, OBJ, Landry, Calloway and should mention the Baker and this game is 100% the Brownies call on how they win. I see the 49ers as over rated with this game being their first challenge.